Activation of Endogenous Stem Cells in the Brain –A Novel Approach to Central Nervous System Disease. Wikström L. Drug Discovery.6:33-35 (2009).  [PDF]

PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity. Guillot TS, Richardson JR, Wang MZ, Li YJ, Taylor TN, Ciliax BJ, Zachrisson O, Mercer A, Miller GW. Neuropeptides. 42(4):423-34. (2008). [PubMed]

Phenotypic characterization of different cell populations from the adult mouse brain using flow cytometry. Hellström N., Patrone C., Zachrisson O. and Kuhn H.G.  Letters in Drug Des. Disc. 4(8):532-539. (2007). [Abstract]

Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease. Bertilsson G, Patrone C, Zachrisson O, Andersson A, Dannaeus K, Heidrich J, Kortesmaa J, Mercer A, Nielsen E, Rönnholm H, Wikström L. J Neurosci Res., (2007). [PubMed]

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment. Williams C, Wirta V, Meletis K, Wikström L, Carlsson L, Frisén J, Lundeberg J. Exp Cell Res., 312:1798-812. (2006)

Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Mohapel P, Frielingsdorf H, Haggblad J, Zachrisson O, Brundin P. Neuroscience. 132:767-76. (2005). [PubMed]

Epidermal growth factor (EGF) withdrawal masks gene expression differences in the study of pituitary adenylate cyclase-activating polypeptide (PACAP) activation of primary neural stem cell proliferation. Sievertzon M, Wirta V, Mercer A, Frisen J, Lundeberg J.  BMC Neurosci. 6:55. (2005). [PubMed] 

Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method. Sievertzon M, Wirta V, Mercer A, Meletis K, Erlandsson R, Wikstrom L, Frisen J, Lundeberg J. BMC Neurosci. 6:28. (2005). [PubMed] 

PACAP promotes neural stem cell proliferation in adult mouse brain. Mercer A, Ronnholm H, Holmberg J, Lundh H, Heidrich J, Zachrisson O, Ossoinak A, Frisen J, Patrone C. J Neurosci Res. 76:205-215 (2004) [PubMed]

Stem Cells and CNS Development. Wikstrom L, Mercer A. Drug Discov Today. 6:1152. (2001)

Papers - Founders

From stem cell to progenitor and back again. Simon A, Frisén J. Cell, 128:825-6. (2007)

Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Curtis MA, Kam M, Nannmark U, Anderson MF, Axell MZ, Wikkelso C, Holtås S, van Roon-Mom WM, Björk-Eriksson T, Nordborg C, Frisén J, Dragunow M, Faull RL, Eriksson PS. Science, 315:1243-9. (2007)

Neocortical neurogenesis in humans is restricted to development. Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Björk-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisén J.  Proc Natl Acad Sci U S A, 103:12564-8. (2006)

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Holmberg, J., Genander, M., Halford, M.M., Annerén, C., Sondell, M., Chumley, M.J., Silvany, R.A., Henkemeyer, M. and Frisén, J.  Cell, 125:1151-63. (2006)

Forensics: Age written in teeth by nuclear tests. Spalding, K., Buchholz, B., Bergman, L.-E., Druis, H. and Frisén, J.  Nature, 437:333-334. (2005)

Retrospective birth dating of cells in humans.Spalding, K., Bhardwaj, R., Buchholz, B, Druid, H and Frisén, J.  Cell, 122:133-143. (2005)

Induction of allodynia limits usefulness of neural stem cells in spinal cord injury; directed differentiation improves outcome. Hofstetter, C.P., Holmström N.A.V., Lilja, J., Schweinhardt, P., Hao, J., Spenger, C., Wiesenfeld-Hallin, Z, Kurpad, S.N., Frisén, J.,and Olson, L.  Nature Neuroscience, 8: 346-353. (2005)

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Holmberg, J., Armulik, A., Senti, K.-A., Edoff, K., Spalding, K., Momma, S., Cassidy, R., Flanagan, J.G. and Frisén, J.  Genes & Development, 19: 462-471. (2005)

Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map. Cutforth, T., Moring, L., Mendelsohn, M., Nemes, A. Shah, N.M., Kim, M.M., Frisén, J. and Axel, R.  Cell, 114: 311-322. (2003)

Carlén, M., Cassidy, R.M., Brismar, H., Smith, G.A., Enquist, LW. and Frisén, J. Current Biology, 12: 606-608. (2002)

Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Holmberg, J., Clarke, D. and Frisén, J.  Nature, 408: 203-206. (2000)

Generalized potential of adult neural stem cells. Clarke, D.L., Johansson, C.B., Johannes Wilbertz, Biborka Veress, Erik Nilsson, Karlström, H., Lendahl, U. and Frisén, J.  Science, 288: 1660-1663. (2000)

Identification of a neural stem cell in the adult mammalian central nervous system. Johansson, C.B., Momma, S., Clarke, D.L., Risling, M., U. Lendahl and Frisén, J.  Cell, 96: 25-34. (1999)